Ion Mobility-Mass Spectrometry: Time-Dispersive Instrumentation

Ion Mobility-Mass Spectrometry: Time-Dispersive Instrumentation

■ CONTENTS Basic Ion Mobility Concepts 1423 Electrostatic and Electrodynamic Fields 1423 Resolving Power 1423 Ion Mobility Techniques 1424 Temporally-Dispersive Ion Mobility 1424 Drift Tube Ion Mobility Spectrometry (DTIMS) 1425 Traveling Wave Ion Mobility Spectrometry (TWIMS) 1426 Overtone Mobility Spectrometry (OMS) 1427 Confinement and Mobility-Selective Release 1428 Trapped Ion Mobility Spe...

Ion Mobility Mass Spectrometry

for more complex analysers for automated sample processing and plant control. The separation time will continue to decrease; in the past there has been limited interest in fast separations but this could change as automated sample processing is developed. Increasing use of coupled techniques such as GC-GC, liquid chromatography-GC, and supercritical Suid chromatography-GC for the separation of ...

Ion Mobility-Mass Spectrometry

Multiplexed ion mobility spectrometry-orthogonal time-of-flight mass spectrometry.

Ion mobility spectrometry (IMS) coupled to orthogonal time-of-flight mass spectrometry (TOF) has shown significant promise for the characterization of complex biological mixtures. The enormous complexity of biological samples (e.g., from proteomics) and the need for both biological and technical analysis replicates imposes major challenges for multidimensional separation platforms with regard t...

Dynamically multiplexed ion mobility time-of-flight mass spectrometry.

Ion mobility spectrometry-time-of-flight mass spectrometry (IMS-TOFMS) has been increasingly used in analysis of complex biological samples. A major challenge is to transform IMS-TOFMS to a high-sensitivity, high-throughput platform, for example, for proteomics applications. In this work, we have developed and integrated three advanced technologies, including efficient ion accumulation in an io...